Muhlethaler à l’université de Genève (Suisse), j’ai mis en évidence que ces neurones et ceux responsables de l’état d’éveil étaient capables de s’inhiber entre eux, illustrant ainsi une boucle d’interaction inhibitrice réciproque. En collaboration avec le laboratoire du Pr. Mes travaux de thèse portaient sur la caractérisation in vitro de neurones localisés dans l’hypothalamus antérieur et responsables du déclenchement du sommeil lent. _J’ai obtenu mon Doctorat en Neurophysiologie en 2002 à l’Université Claude Bernard (Lyon, France). All rights reserved.Laboratoire Plasticité du Cerveau, CNRS UMR8249
#J ai rejoin trial#
The REJOIN trial could lay the foundation for transdisciplinary research that bridges the gap between clinical and public health perspectives in healthy aging, with the opportunity to translate clinical interventions into non-pharmacological tools for a growing, yet underserved population of older survivors.ĪI-related arthralgia Breast cancer survivors Geriatric oncology Joint pain Physical activity.Ĭopyright © 2021 Elsevier Ltd. REJOIN is one of the first trials to exclusively target older BCS using a self-management intervention, informed by geriatric assessment and exercise physiology, to improve health outcomes in survivorship.
#J ai rejoin plus#
We will conduct geriatric assessments plus measurements of exercise, joint pain, and AI adherence (baseline, 4, 6 and 12 months). The 16-week intervention program includes: 8-weeks of supervised sessions plus 8-weeks of self-guided home sessions with periodic phone coaching. We will adapt an evidence-based physical activity program for older adults that includes bi-weekly, supervised exercise sessions plus 30 min of education.
This randomized controlled pilot trial will include sedentary BCS, 65 years and older, diagnosed with stage I-III hormone-sensitive breast cancer, who have completed primary cancer treatment and are planning to initiate AIs. The Using Exercise to Relieve Joint Pain in Older Breast Cancer Survivors (REJOIN) Trial will evaluate the efficacy of a self-management intervention (exercise + education) to increase knowledge/self-efficacy for symptom management, reduce joint pain and potentially increase AI adherence in older BCS planning to take AIs. Joint pain is a common AI-related symptom that is associated with low AI adherence. AI Adherence is suboptimal, especially in older BCS. Hershey Medical Center, Hershey, PA, United States of America Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, State College, PA, United States of America.Īromatase Inhibitors (AIs) are recommended for survival in post-menopausal breast cancer survivors (BCS) with hormone-sensitive disease. 6 Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, United States of America Cancer Institute, The Pennsylvania State University, Milton S.
5 Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, United States of America.Hershey Medical Center, Hershey, PA, United States of America. 4 Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, United States of America Department of Medicine, The Pennsylvania State University, College of Medicine, Milton S.3 Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.Hershey Medical Center, Hershey, PA, United States of America Department of Medicine, The Pennsylvania State University, College of Medicine, Milton S. Electronic address: 2 Cancer Institute, The Pennsylvania State University, Milton S.
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